The AGM brought together people from different professional backgrounds (scientists, doctors, IT experts, mathematicians and patient representatives). The main aims of the meeting were:
- to update members on progress within each group working on different parts of the project, known as ‘work packages’
- to deepen the integration and collaboration among all work packages (WPs)
- to discuss current issues and how to resolve them
- and identify future objectives
AirPROM has entered in its 3rd year and has already achieved many objectives, and made some interesting discoveries. These and other key results will be confirmed and presented through academic publications and knowledge sharing platforms, such as the partner project eTRIKS.
The main challenge faced by the researchers continues to be integrating models and making them work in practice. The focus of the project now is to integrate the WPs, develop reliable computer models and turn them into useful tools for clinicians and patients, which can lead to personalised treatment of patients.
Summary of each WP’s activities and targets for the year ahead:
- WP1 has collected patient information from 594 patients. WP1 now aims to bring this together with data from existing projects (EvA, U-BIOPRED, CRTH2, Roche). WP1 will start longitudinal assessment, prepare a publication plan and show success through knowledge platforms. The main problem identified is when the data shared between projects is incomplete
- WP2 is using data from different sub-types of asthma and COPD to create models that predict how the disease will develop.
- WP3 aims to deliver reliable models of the airways. Separate models are being developed to model cells in the walls of the airways, and lung tissue.
- WP4 is using computer tomography (CT) imaging and computational fluid dynamic (CFD) techniques to work out how to model the lungs and build the most accurate computer models. CT imaging looks at slices of specific areas of the body, whilst CFD uses mathematics to looks at how liquids flow and work out how fluids flow in different areas of the body.
- WP5 is developing a set of data for people with different stages of lung disease, identifying areas where the WPs can work more closely together to join up the different modelsWP6 is using data from patients to work out the structure and function of the small airways in asthma and COPD. A number of models of the small airways have been produced. Next, they will bring these models together.
- WP7 will provide a data management system to bring together clinical trials and data.
- WP8 is looking for relationships between the different models and trying to streamline the process of model development so that the fewest models possible are needed to produce the most accurate results.
- WP9 is raising public and professional awareness of the project, and will continue to develop promotional resources, such as USB sticks to give out at scientific conferences. They have helped develop a publication strategy for the project, and confirmed a place for AirPROM at the European Respiratory Society Congress in Barcelona in September 2013.
- At the meeting, clinical trials including the Anti-Eosinophils Study and Thermoplasty Study were also discussed.
If you would like to stay up to date with the project, or have any questions, you can: